GLP-1 Agonists: Are They a Breakthrough for GLP-1, Weight Loss, and Blood Sugar Control?

GLP-1 Agonists | Breakthrough for Weight Loss and Blood Sugar

GLP-1 Agonists Overview

GLP-1 agonists have gained attention as effective treatments to treat obesity. Not only for managing blood glucose or blood sugar levels in diabetes. But also for promoting weight loss in individuals with a body mass index of 30 or higher. Or a BMI of 27 or higher with at least one weight-related health problem. 

These medications mimic the effects of GLP-1 in the body. They help the body regulate blood sugar levels and can promote weight loss by slowing gastric emptying and reducing appetite.

Is GLP-1 the Same as Ozempic?

GLP-1 (Glucagon-Like Peptide-1) is a natural hormone in the body that stimulates insulin release in response to food intake. Ozempic, FDA approved is a brand name for Semaglutide. It is a synthetic GLP-1 receptor agonist that treats type 2 diabetes and aid in weight loss.

What is the Truth About Ozempic?

Ozempic (Semaglutide) has shown in clinical trials to significantly effective as a diabetes drug medical. To lower blood sugar, and reduce A1C levels. As well as promote significant weight loss thereafter. It also lowers the risk of serious cardiovascular problems.

Such as heart disease, obesity, and diabetes. Doctors administer the drug via subcutaneous injection. Eventually proven safety profile in managing type 2 diabetes and promoting weight reduction.

GLP-1 Agonist

Does Trulicity Cause Weight Loss?

Trulicity (dulaglutide) is another GLP-1 receptor agonist. Evidently shown to promote weight loss. In addition to improving both blood pressure and sugar control. It works similarly to Ozempic by stimulating insulin release and reducing appetite.

How Do GLPs-1 Work?

They work by mimicking the effects of GLP-1. For instance enhancing insulin secretion, inhibiting glucagon release, slowing gastric emptying, and promoting satiety.

What Are the Different Types of GLP-1 Agonists Available?

  • Dulaglutide (Trulicity).

  • Exenatide (Byetta, Bydureon)

  • Liraglutide (Victoza, Saxenda).

  • Semaglutide (Ozempic, Wegovy).

GLP-1 receptor agonist

Weight Loss Effectiveness

Which GLP-1 is best for weight loss?

Semaglutide (Wegovy, Ozempic) is the most effective for weight loss compared to other GLP-1 agonists. Due to its strong appetite suppression and metabolic effects. They reduce appetite, increase feelings of fullness, and slow down stomach emptying. As a result, it lowers caloric intake.

How fast is weight loss with Farxiga?

Farxiga is an SGLT-2 inhibitor, and also helps with weight loss but through different mechanisms. It helps with weight loss by increasing glucose excretion in the urine. Weight loss with Farxiga will vary. Although patients will lose weight gradually over several months not rapid weight loss like GLP-1 agonists.

What are the typical weight loss results with GLP-1 agonists?

Typical weight loss in patients used with GLP-1 agonists like Ozempic and Wegovy is 5-10% of body weight. So if you weigh 200lbs you might lose 10-20lbs over a few months. Additionally, improves blood sugar, blood pressure, and cholesterol levels.

Weight Loss Medications

Comparison with Other Diabetes Medication

How do GLP-1 agonists compare to other diabetes medications?

Compared to traditional diabetes meds like metformin or sulfonylureas. They are more effective for weight loss. Metformin may lead to some weight loss. However, GLP-1 receptor agonists are better for weight reduction. Because of their appetite-suppressed slowed gastric emptying which makes you feel full for longer.

What are the differences between GLP-1 agonists and SGLT-2 inhibitors for body weight loss?

GLP-1 agonists and SGLT-2 inhibitors work differently for weight loss. GLP-1 stimulates insulin release, suppresses glucagon release, lowers blood glucose and sugar levels, and reduces appetite.

SGLT-2 inhibitors also lower blood sugar levels and glucose by increasing glucose excretion in urine and resulting in calorie loss and weight loss.

Healthy Life changes

What diabetic pills help you lose weight?

Diabetes pills class of drugs like GLP-1 agonists and SGLT-2 inhibitors (Farxiga). Particularly, diabetes drugs are known for their weight loss. They work differently but both medications help with weight loss in diabetic patients.

How quickly will you lose excess weight while on metformin?

Metformin, a common type 2 diabetes medication, can lead to some weight loss over time. Metformin weight loss is gradual and usually takes a few months with regular use.

Does taking metformin cause weight loss?

Metformin results may vary. Some people may lose a lot of weight. But losing 30 lbs on metformin alone without a healthy diet and exercise may be tough.

Metformin’s main job is to make diabetes drugs improve insulin sensitivity and glucose control, not weight loss. Anabolic effects, GLP-1 agonists cause weight loss by reducing appetite and slowing gastric emptying.

So they are the better choice to release insulin for diabetes drug type 2 diabetes medications for diabetics who struggle more insulin and with weight management.


Side Effects and Safety

What are the common side effects of GLP-1 agonists?

GI side effects include nausea, vomiting, diarrhea, and constipation. Some people may also experience injection site reactions, headaches, or dizziness. These side effects go away with continued use.

Are GLP-1 agonists safe for long-term use?

They are safe for long-term use for both type 2 diabetes and obesity. However, GLP-1 agonists are not recommended for individuals with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia. They reduce heart disease or cardiovascular risk associated with diabetes and support weight loss over extended periods.

How to manage the side effects of GLP-1 agonists?

Doctors recommend starting with a lower dose. Then gradually increasing it to higher doses to help with tolerance. Adjusting injection timing with meals and anti-nausea medication can also help with gastrointestinal side effects.

Will you gain weight back after stopping Ozempic?

Weight gain is possible after stopping Ozempic. Especially if a healthy lifestyle, eating, and exercise habits are not continued. However, doctors advise patients to continue healthy lifestyle changes and modifications after treatment. Furthermore, maintain the weight loss achieved with GLP-1 agonists.

GLP-1 Agonists

Usage and Prescription

How long can I be on Ozempic for weight loss?

The length of time you can be on Ozempic for weight loss. Eventually depends on your response and your healthcare provider. Studies have shown that continuous use under medical supervision.

Consequently, helps people lose weight and maintain sustainable weight loss over time. However,  healthcare providers should monitor the process. To further assess ongoing efficacy and safety.

What are the guidelines for starting GLP-1 agonists?

Criteria for starting include eligibility based on weight, diabetes status, and cardiovascular risk factors. 

Wegovy Ozempic

Can they be used off-label for weight loss drugs?

While not approved for weight loss in patients with type 2 diabetes, GLP-1 agonist medications like Ozempic used off-label for weight loss in people without diabetes. Doctors recommend using off-label injectable medications only after consultation with your healthcare provider. Finally to weigh the medications’ benefits and risks.

Are Wegovy and Ozempic the Same?

Wegovy (Semaglutide) and Ozempic are both medications approved for containing the same class of drugs same active ingredient, semaglutide. Wegovy, however, is a drug specifically approved for weight management for individuals with obesity or heavier body weight. Particularly have at least one weight-related condition.

How is Ozempic prescribed for weight loss?

Doctors prescribe Ozempic as a once-a-week subcutaneous injection. Based on the medical history and weight loss goals, they will determine the right low or higher dose. Besides this, follow-up appointments are important to monitor progress and adjust treatment as needed.

Call us or schedule a teleconsultation to further inquire about available medical weight loss treatments and programs or bariatric surgery. 

Picture of Dr. A. Christopher Ibikunle MD FACS
Dr. A. Christopher Ibikunle MD FACS
Dr A. Christopher Ibikunle (MD, FACS) is a distinguished surgeon with a rich academic and clinical background. After completing his residency at the Cleveland Clinic Foundation, he served as an Active Staff and Assistant Professor of Surgery. Currently, he is a Professor of Surgery at Augusta University/University of Georgia Medical Partnership and a Lead Preceptor for several institutions, including Morehouse University and Philadelphia College of Osteopathic Medicine. Dr. Chris is a fellow of the American College of Surgeons and a member of the American Society for Metabolic and Bariatric Surgery, committed to advancing surgery and patient care.
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